Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 17 Researches
7.4
USERS' SCORE
Good
Based on 13 Reviews
8
Supplement Facts
Serving Size: 1 Vegetarian Capsule
Amount Per Serving
%DV
Vitamin E (as D-alpha tocopheryl succinate)
20.1 mg
134%
Selenium (as Se-Methyl L-Selenocysteine, L-selenomethionine (yeast-free), sodium selenite)
200 mcg
364%
Top Medical Research Studies
8
We explored the impact of selenium nanoparticles, known for their potential anti-cancer properties, on aggressive prostate cancer cells, specifically the PC-3 line. The study focused on understanding how sub-toxic levels of selenium functionalized nanoparticles affect cell proliferation and their intracellular behavior.
By utilizing advanced imaging techniques and careful cryopreparation, we aimed to preserve the integrity of the cancer cells while analyzing the distribution of these nanoparticles within them. Our findings revealed that nanoparticles coated with bovine serum albumin (BSA) reduced the migration capability of the cancer cells more effectively than those coated with chitosan.
This difference may be attributed to the BSA coating's ability to prevent harmful interactions with the cell membranes, which in turn limits the generation of reactive oxygen species that can damage cells. Most intriguingly, we observed that these selenium nanoparticles localized in both the mitochondria and lysosome-related organelles within the cells. The presence of nanoparticles in the mitochondria might explain the significant reduction in the PC-3 cells' ability to proliferate.
Overall, our investigation highlights the promising role selenium nanoparticles can play in cancer treatment strategies, providing valuable insights for further research into their cytotoxic mechanisms against prostate cancer.
By utilizing advanced imaging techniques and careful cryopreparation, we aimed to preserve the integrity of the cancer cells while analyzing the distribution of these nanoparticles within them. Our findings revealed that nanoparticles coated with bovine serum albumin (BSA) reduced the migration capability of the cancer cells more effectively than those coated with chitosan.
This difference may be attributed to the BSA coating's ability to prevent harmful interactions with the cell membranes, which in turn limits the generation of reactive oxygen species that can damage cells. Most intriguingly, we observed that these selenium nanoparticles localized in both the mitochondria and lysosome-related organelles within the cells. The presence of nanoparticles in the mitochondria might explain the significant reduction in the PC-3 cells' ability to proliferate.
Overall, our investigation highlights the promising role selenium nanoparticles can play in cancer treatment strategies, providing valuable insights for further research into their cytotoxic mechanisms against prostate cancer.
Read More
8
Our study focused on understanding how various forms of selenium can impact prostate cancer, specifically the PC-3 cell line. We utilized a systematic approach called Mixture Design Response Surface Methodology to find the most effective combinations of selenium compounds, including sodium selenite, methylseleninic acid, and nano-selenium.
We began by testing each selenium compound individually to determine their effectiveness at reducing cancer cell viability. Interestingly, we found that the 50:50 mixture of methylseleninic acid and sodium selenite yielded the best results, showcasing impressive antineoplastic potential. However, the combination of nano-selenium with selenite did not demonstrate any additional benefits, suggesting that they might work through similar mechanisms.
This study underscores the importance of recognizing the distinct effects of different selenium compounds when considering them as treatments for prostate cancer. Our findings encourage further research in this area, as the choice and combination of selenium forms could significantly influence treatment outcomes. Overall, selenium shows promise as a potential weapon in the fight against prostate cancer, but we need to keep exploring the variations of these compounds to fully understand their capabilities.
We began by testing each selenium compound individually to determine their effectiveness at reducing cancer cell viability. Interestingly, we found that the 50:50 mixture of methylseleninic acid and sodium selenite yielded the best results, showcasing impressive antineoplastic potential. However, the combination of nano-selenium with selenite did not demonstrate any additional benefits, suggesting that they might work through similar mechanisms.
This study underscores the importance of recognizing the distinct effects of different selenium compounds when considering them as treatments for prostate cancer. Our findings encourage further research in this area, as the choice and combination of selenium forms could significantly influence treatment outcomes. Overall, selenium shows promise as a potential weapon in the fight against prostate cancer, but we need to keep exploring the variations of these compounds to fully understand their capabilities.
Read More
8
We explored how selenium-containing compounds impact prostate cancer, particularly focusing on their potential as both anticancer agents and radical scavengers. In our study, we synthesized a new type of molecule called acylselenourea derivatives, based on structures similar to those found in natural products.
Through various tests, we evaluated these compounds for their ability to fight cancer cells in prostate, colon, lung, and breast cancers, as well as their effectiveness in scavenging free radicals that can damage cells. The results were promising, revealing that some of these new selenium compounds demonstrated strong anticancer activity by inducing cell death through a process known as apoptosis.
Additionally, they showed radical scavenging capability that performed comparably to well-known antioxidants like ascorbic acid and trolox. This suggests that introducing selenium into these small molecules could yield dual benefits, paving the way for future developments in cancer treatment approaches.
Overall, our findings highlight the exciting potential of selenium derivatives in treating prostate cancer and the importance of continued research in this area.
Through various tests, we evaluated these compounds for their ability to fight cancer cells in prostate, colon, lung, and breast cancers, as well as their effectiveness in scavenging free radicals that can damage cells. The results were promising, revealing that some of these new selenium compounds demonstrated strong anticancer activity by inducing cell death through a process known as apoptosis.
Additionally, they showed radical scavenging capability that performed comparably to well-known antioxidants like ascorbic acid and trolox. This suggests that introducing selenium into these small molecules could yield dual benefits, paving the way for future developments in cancer treatment approaches.
Overall, our findings highlight the exciting potential of selenium derivatives in treating prostate cancer and the importance of continued research in this area.
Read More
Most Useful Reviews
9
Overall health
This excellent supplement prevents cancer, boosts immunity, and improves the circulatory system. Selenium protects against free radicals and is essential for thyroid hormone production.
Read More
6
Thyroid function
4 people found this helpful
Selenium is crucial for thyroid health and combats prostate cancer. It includes vitamin E, which is beneficial. I take one pill daily before going to sleep.
Read More
7.5
Post-cancer benefit
3 people found this helpful
This excellent supplement has been part of my routine for the last 18-20 months as a post-cancer patient. I find it incredibly beneficial for my health.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 17 Researches
7.4
- All Researches
9.5
We aimed to explore how selenium (Se) and zinc (Zn) levels affect the survival of men diagnosed with prostate cancer. In a study conducted in Poland from 2009 to 2015, we enrolled 338 prostate cancer patients and measured their serum levels of these micronutrients before they started any treatment.
By categorizing participants into quartiles based on their Se and Zn levels, we utilized Cox regression to evaluate the relationship between these levels and patient survival. Our findings revealed a notable interaction between selenium and zinc, suggesting that higher combined levels of these micronutrients correlate with increased survival rates in prostate cancer patients.
Specifically, patients in the highest quartile of both Se and Zn showed a remarkably high hazard ratio (HR = 20.9) compared to those in the lowest quartile. However, it’s important to note that while the interaction is significant, our study does not isolate the effects of selenium from zinc alone. Therefore, further research is warranted to better understand optimal selenium and zinc levels for different populations and how they might contribute to prostate cancer outcomes.
By categorizing participants into quartiles based on their Se and Zn levels, we utilized Cox regression to evaluate the relationship between these levels and patient survival. Our findings revealed a notable interaction between selenium and zinc, suggesting that higher combined levels of these micronutrients correlate with increased survival rates in prostate cancer patients.
Specifically, patients in the highest quartile of both Se and Zn showed a remarkably high hazard ratio (HR = 20.9) compared to those in the lowest quartile. However, it’s important to note that while the interaction is significant, our study does not isolate the effects of selenium from zinc alone. Therefore, further research is warranted to better understand optimal selenium and zinc levels for different populations and how they might contribute to prostate cancer outcomes.
Read More
9
We sought to understand how selenium, specifically in the form of lentinan-functionalized selenium nanoparticles (LET-SeNPs), can improve radiotherapy outcomes for prostate cancer. Our investigation showed that when these nanoparticles were combined with X-ray therapy, they significantly hampered the growth of prostate cancer cells and their ability to form colonies. This effect was greater than either treatment alone.
The mechanism behind this enhanced sensitivity involved a complex interplay of cellular pathways. We observed that LET-SeNPs helped induce more robust apoptosis, or programmed cell death, by targeting various signaling routes in the cancer cells, such as the p53, MAPK, and AKT pathways. Moreover, they elevated levels of reactive oxygen species (ROS), which are known to promote apoptosis, while also decreasing the expression of Thioredoxin reductase, an enzyme that aids in DNA repair.
In animal models, the combination therapy proved effective in slowing down tumor growth, reinforcing our findings from the lab. These results suggest that using LET-SeNPs alongside X-ray therapy could potentially transform prostate cancer treatment, enhancing its effectiveness while possibly reducing side effects. Overall, we believe that selenium-modified nanoparticles hold significant promise for advancing cancer therapies.
The mechanism behind this enhanced sensitivity involved a complex interplay of cellular pathways. We observed that LET-SeNPs helped induce more robust apoptosis, or programmed cell death, by targeting various signaling routes in the cancer cells, such as the p53, MAPK, and AKT pathways. Moreover, they elevated levels of reactive oxygen species (ROS), which are known to promote apoptosis, while also decreasing the expression of Thioredoxin reductase, an enzyme that aids in DNA repair.
In animal models, the combination therapy proved effective in slowing down tumor growth, reinforcing our findings from the lab. These results suggest that using LET-SeNPs alongside X-ray therapy could potentially transform prostate cancer treatment, enhancing its effectiveness while possibly reducing side effects. Overall, we believe that selenium-modified nanoparticles hold significant promise for advancing cancer therapies.
Read More
9
We explored an innovative approach to treating prostate cancer by developing a unique prodrug that combines a potent HDAC inhibitor with selenium. This new compound, known as SeSA-DCA, was designed to effectively target cancer cells while minimizing side effects.
The study assessed how SeSA-DCA works in the body and its impact on various prostate cancer cell lines. We observed that this compound not only inhibited cancer cell growth but also prompted cell death and reduced metastasis significantly. Our animal studies revealed that SeSA-DCA led to notable tumor shrinkage without causing serious toxicity, outperforming even the standard treatment of docetaxel.
Additionally, we found that SeSA-DCA was stable in the body's environment and broke down rapidly in the tumor area, releasing its active components. This dual-action mechanism makes SeSA-DCA a promising candidate for prostate cancer therapy, potentially improving outcomes for patients while offering a safer alternative to traditional treatments. Overall, our findings suggest that selenium combined with HDAC inhibition can play a crucial role in advancing prostate cancer treatment strategies.
The study assessed how SeSA-DCA works in the body and its impact on various prostate cancer cell lines. We observed that this compound not only inhibited cancer cell growth but also prompted cell death and reduced metastasis significantly. Our animal studies revealed that SeSA-DCA led to notable tumor shrinkage without causing serious toxicity, outperforming even the standard treatment of docetaxel.
Additionally, we found that SeSA-DCA was stable in the body's environment and broke down rapidly in the tumor area, releasing its active components. This dual-action mechanism makes SeSA-DCA a promising candidate for prostate cancer therapy, potentially improving outcomes for patients while offering a safer alternative to traditional treatments. Overall, our findings suggest that selenium combined with HDAC inhibition can play a crucial role in advancing prostate cancer treatment strategies.
Read More
9
We conducted a systematic exploration of natural extracts, with a particular focus on selenium, and its role in managing prostate cancer. The available evidence includes findings from various studies, including our analysis, which assessed the effectiveness of selenium alone and in combination with other extracts, such as silybin.
While selenium was noted in our findings, we found that its effectiveness is not straightforward. Specifically, the interaction between selenium and silybin complicated our ability to isolate the impact of selenium on its own. Thus, it became clear that, although some benefits arise from its combined use, we couldn’t definitively conclude that selenium alone delivers significant advantages for prostate cancer treatment.
Overall, the insights from our network meta-analysis suggest that while silybin and selenium together show promise, we need more studies to establish the detailed benefits and safety of selenium as a standalone treatment for prostate cancer. Those considering natural extract options should proceed with caution, keeping in mind the current limitations in evidence.
While selenium was noted in our findings, we found that its effectiveness is not straightforward. Specifically, the interaction between selenium and silybin complicated our ability to isolate the impact of selenium on its own. Thus, it became clear that, although some benefits arise from its combined use, we couldn’t definitively conclude that selenium alone delivers significant advantages for prostate cancer treatment.
Overall, the insights from our network meta-analysis suggest that while silybin and selenium together show promise, we need more studies to establish the detailed benefits and safety of selenium as a standalone treatment for prostate cancer. Those considering natural extract options should proceed with caution, keeping in mind the current limitations in evidence.
Read More
9
Targeted selenium treatment effective
We investigated how selenium, combined with chemoradiotherapy, could target and treat prostate cancer, specifically in the LNCaP cell line. The study employed a sophisticated design involving methotrexate-selenium nanostructures loaded with Myc decoy oligodeoxynucleotides. This innovative approach aimed to enhance treatment effectiveness when paired with X-irradiation.
Throughout our experiments, we observed that these targeted nanostructures showcased promising characteristics. The selenium nanoparticles displayed a size of around 40 nanometers and a suitable negative charge, indicating a well-structured composite. Notably, they demonstrated hemocompatibility, meaning they are likely safe when interacting with blood cells at lower concentrations.
The results were encouraging: the combination therapy led to significant cell growth inhibition and about 57% apoptosis in the cancer cells. We also noted a substantial cell cycle arrest in the G2/M phase and a migration inhibition of up to 90%. These findings suggest that selenium, when used as part of a carefully designed nanostructure, can enhance the effectiveness of therapies against prostate cancer.
Throughout our experiments, we observed that these targeted nanostructures showcased promising characteristics. The selenium nanoparticles displayed a size of around 40 nanometers and a suitable negative charge, indicating a well-structured composite. Notably, they demonstrated hemocompatibility, meaning they are likely safe when interacting with blood cells at lower concentrations.
The results were encouraging: the combination therapy led to significant cell growth inhibition and about 57% apoptosis in the cancer cells. We also noted a substantial cell cycle arrest in the G2/M phase and a migration inhibition of up to 90%. These findings suggest that selenium, when used as part of a carefully designed nanostructure, can enhance the effectiveness of therapies against prostate cancer.
Read More
User Reviews
USERS' SCORE
Good
Based on 13 Reviews
8
- All Reviews
- Positive Reviews
- Negative Reviews
9
Overall health
This excellent supplement prevents cancer, boosts immunity, and improves the circulatory system. Selenium protects against free radicals and is essential for thyroid hormone production.
Read More
6
Thyroid function
4 people found this helpful
Selenium is crucial for thyroid health and combats prostate cancer. It includes vitamin E, which is beneficial. I take one pill daily before going to sleep.
Read More
7.5
Post-cancer benefit
3 people found this helpful
This excellent supplement has been part of my routine for the last 18-20 months as a post-cancer patient. I find it incredibly beneficial for my health.
Read More
7.5
Immunity boost
1 people found this helpful
I have been using this product for several years as it has proven effective in building immunity against various types of cancer. It’s easy to take and reasonably priced.
Read More
7.5
Prostate support
1 people found this helpful
This product works wonderfully, especially when combined with zinc, enhancing immunity and benefiting prostate health, alongside supplements like pumpkin seeds.
Read More
Frequently Asked Questions
9
Prostate relief
9 people found this helpful
Constantly purchasing this selenium for my dad. He often praises its efficacy. Issues related to prostate cancer and bladder discomfort have significantly improved.
7.5
Post-cancer benefit
3 people found this helpful
This excellent supplement has been part of my routine for the last 18-20 months as a post-cancer patient. I find it incredibly beneficial for my health.
8.5
Helps prostate health
I regularly use this product. It’s of good quality with effective ingredients. It has helped me with my prostate, and I find the size comfortable and easy to swallow.
7.5
Prostate support
1 people found this helpful
This product works wonderfully, especially when combined with zinc, enhancing immunity and benefiting prostate health, alongside supplements like pumpkin seeds.
6
Cancer fighting
Selenium is a vital trace element that combats atherosclerosis, has anti-cancer properties, and strengthens the immune system. I recommend this yeast-free form, particularly with vitamin E.
7.5
Essential supplement
I highly recommend this product. Its composition is effective for the price. As a mineral nutrient, it enhances antioxidant immunity. I trust Life Extension for its quality and verified efficacy. This supplement is essential, particularly if you have selenium deficiency, which can lead to cancer, cardiovascular issues, and skin health problems. It contains 100 tablets at an affordable price. Although taken less frequently than once a day, it is manageable.
6
Thyroid function
4 people found this helpful
Selenium is crucial for thyroid health and combats prostate cancer. It includes vitamin E, which is beneficial. I take one pill daily before going to sleep.
7.5
Cancer prevention
2 people found this helpful
I regularly take selenium as it is essential for cancer prevention. This product combines three forms of selenium with vitamin E, which is ideal for my needs.
8
Selenium may reduce prostate cancer risk
We investigated the role of selenium in reducing the risk of prostate cancer, particularly focusing on how it may benefit men's health. The exploration centered on the idea that dietary supplements containing selenium, along with other antioxidants like vitamins C and E, could offer some protective effects against this common cancer.
Our findings highlighted that there is some evidence suggesting a potential benefit. For instance, research indicated that men who included selenium in their daily regimen experienced a reduced risk of developing prostate cancer. However, we also noted that results across various studies have been mixed.
It is important to recognize that while certain studies showed encouraging outcomes, others did not find significant effects. This inconsistency means we need to approach selenium's role carefully. We must consider it as part of a broader dietary strategy rather than a standalone solution.
Ultimately, while selenium supplementation could have positive implications for prostate cancer risk, more extensive research is necessary to fully understand its effectiveness and to clarify how it fits into overall cancer prevention strategies.
Our findings highlighted that there is some evidence suggesting a potential benefit. For instance, research indicated that men who included selenium in their daily regimen experienced a reduced risk of developing prostate cancer. However, we also noted that results across various studies have been mixed.
It is important to recognize that while certain studies showed encouraging outcomes, others did not find significant effects. This inconsistency means we need to approach selenium's role carefully. We must consider it as part of a broader dietary strategy rather than a standalone solution.
Ultimately, while selenium supplementation could have positive implications for prostate cancer risk, more extensive research is necessary to fully understand its effectiveness and to clarify how it fits into overall cancer prevention strategies.
9
We sought to understand how selenium, specifically in the form of lentinan-functionalized selenium nanoparticles (LET-SeNPs), can improve radiotherapy outcomes for prostate cancer. Our investigation showed that when these nanoparticles were combined with X-ray therapy, they significantly hampered the growth of prostate cancer cells and their ability to form colonies. This effect was greater than either treatment alone.
The mechanism behind this enhanced sensitivity involved a complex interplay of cellular pathways. We observed that LET-SeNPs helped induce more robust apoptosis, or programmed cell death, by targeting various signaling routes in the cancer cells, such as the p53, MAPK, and AKT pathways. Moreover, they elevated levels of reactive oxygen species (ROS), which are known to promote apoptosis, while also decreasing the expression of Thioredoxin reductase, an enzyme that aids in DNA repair.
In animal models, the combination therapy proved effective in slowing down tumor growth, reinforcing our findings from the lab. These results suggest that using LET-SeNPs alongside X-ray therapy could potentially transform prostate cancer treatment, enhancing its effectiveness while possibly reducing side effects. Overall, we believe that selenium-modified nanoparticles hold significant promise for advancing cancer therapies.
The mechanism behind this enhanced sensitivity involved a complex interplay of cellular pathways. We observed that LET-SeNPs helped induce more robust apoptosis, or programmed cell death, by targeting various signaling routes in the cancer cells, such as the p53, MAPK, and AKT pathways. Moreover, they elevated levels of reactive oxygen species (ROS), which are known to promote apoptosis, while also decreasing the expression of Thioredoxin reductase, an enzyme that aids in DNA repair.
In animal models, the combination therapy proved effective in slowing down tumor growth, reinforcing our findings from the lab. These results suggest that using LET-SeNPs alongside X-ray therapy could potentially transform prostate cancer treatment, enhancing its effectiveness while possibly reducing side effects. Overall, we believe that selenium-modified nanoparticles hold significant promise for advancing cancer therapies.
9
We explored an innovative approach to treating prostate cancer by developing a unique prodrug that combines a potent HDAC inhibitor with selenium. This new compound, known as SeSA-DCA, was designed to effectively target cancer cells while minimizing side effects.
The study assessed how SeSA-DCA works in the body and its impact on various prostate cancer cell lines. We observed that this compound not only inhibited cancer cell growth but also prompted cell death and reduced metastasis significantly. Our animal studies revealed that SeSA-DCA led to notable tumor shrinkage without causing serious toxicity, outperforming even the standard treatment of docetaxel.
Additionally, we found that SeSA-DCA was stable in the body's environment and broke down rapidly in the tumor area, releasing its active components. This dual-action mechanism makes SeSA-DCA a promising candidate for prostate cancer therapy, potentially improving outcomes for patients while offering a safer alternative to traditional treatments. Overall, our findings suggest that selenium combined with HDAC inhibition can play a crucial role in advancing prostate cancer treatment strategies.
The study assessed how SeSA-DCA works in the body and its impact on various prostate cancer cell lines. We observed that this compound not only inhibited cancer cell growth but also prompted cell death and reduced metastasis significantly. Our animal studies revealed that SeSA-DCA led to notable tumor shrinkage without causing serious toxicity, outperforming even the standard treatment of docetaxel.
Additionally, we found that SeSA-DCA was stable in the body's environment and broke down rapidly in the tumor area, releasing its active components. This dual-action mechanism makes SeSA-DCA a promising candidate for prostate cancer therapy, potentially improving outcomes for patients while offering a safer alternative to traditional treatments. Overall, our findings suggest that selenium combined with HDAC inhibition can play a crucial role in advancing prostate cancer treatment strategies.
7
We explored how Selol, a selenium compound, affects prostate cancer in a controlled study using mice. The research focused on evaluating tumor morphology and the balance between oxidative and antioxidative factors in both healthy and tumor-bearing mice treated with Selol. By measuring various biochemical markers, we aimed to uncover the potential anticancer effects of this selenium form.
Our findings reveal that Selol notably influences tumor cell structure, suggesting it may promote cell death via necrosis. In healthy mice, long-term Selol treatment boosted antioxidant enzyme activity, which is crucial for managing oxidative stress. However, the situation was more complex in cancer cells, where oxidative stress appeared to trigger their protective mechanisms.
We found that Selol might be more effective against smaller tumors, but caution is needed. In larger, more advanced tumors, it could actually accelerate growth when used alone. This leads us to believe that Selol might work best in combination with other therapies or for preventing recurrence, rather than as a standalone treatment.
Overall, this research opens doors to better understanding how selenium can be utilized in prostate cancer therapy while emphasizing the importance of further investigations to determine its most effective application.
Our findings reveal that Selol notably influences tumor cell structure, suggesting it may promote cell death via necrosis. In healthy mice, long-term Selol treatment boosted antioxidant enzyme activity, which is crucial for managing oxidative stress. However, the situation was more complex in cancer cells, where oxidative stress appeared to trigger their protective mechanisms.
We found that Selol might be more effective against smaller tumors, but caution is needed. In larger, more advanced tumors, it could actually accelerate growth when used alone. This leads us to believe that Selol might work best in combination with other therapies or for preventing recurrence, rather than as a standalone treatment.
Overall, this research opens doors to better understanding how selenium can be utilized in prostate cancer therapy while emphasizing the importance of further investigations to determine its most effective application.
3
Selenium's limited role in prostate cancer
We examined the effects of selenium on prostate cancer, focusing on its potential to prevent and treat the disease. Research has shown a connection between selenium levels and prostate cancer progression, particularly through observational studies. However, the results from randomized controlled trials revealed that selenium supplementation does not prevent prostate cancer, with a hazard ratio indicating no significant benefit (HR: 0.95; 95% CI 0.80-1.13).
This discrepancy between observational findings and randomized studies suggests that individual genetic differences, specifically selenoprotein single nucleotide polymorphisms, might influence selenium's effectiveness.
Despite the lack of evidence supporting selenium's preventative effects, we noted that it demonstrates considerable promise when used in combination with other therapies for prostate cancer. Emerging research has highlighted selenium's role in various biological processes relevant to cancer, including androgen receptor signaling, antioxidative functions, and immune regulation.
In summary, while selenium shows potential benefits in certain contexts, it currently does not hold the key to preventing prostate cancer on its own. Nonetheless, its varied properties could pave the way for future treatments and drug development.
This discrepancy between observational findings and randomized studies suggests that individual genetic differences, specifically selenoprotein single nucleotide polymorphisms, might influence selenium's effectiveness.
Despite the lack of evidence supporting selenium's preventative effects, we noted that it demonstrates considerable promise when used in combination with other therapies for prostate cancer. Emerging research has highlighted selenium's role in various biological processes relevant to cancer, including androgen receptor signaling, antioxidative functions, and immune regulation.
In summary, while selenium shows potential benefits in certain contexts, it currently does not hold the key to preventing prostate cancer on its own. Nonetheless, its varied properties could pave the way for future treatments and drug development.
9
We conducted a systematic exploration of natural extracts, with a particular focus on selenium, and its role in managing prostate cancer. The available evidence includes findings from various studies, including our analysis, which assessed the effectiveness of selenium alone and in combination with other extracts, such as silybin.
While selenium was noted in our findings, we found that its effectiveness is not straightforward. Specifically, the interaction between selenium and silybin complicated our ability to isolate the impact of selenium on its own. Thus, it became clear that, although some benefits arise from its combined use, we couldn’t definitively conclude that selenium alone delivers significant advantages for prostate cancer treatment.
Overall, the insights from our network meta-analysis suggest that while silybin and selenium together show promise, we need more studies to establish the detailed benefits and safety of selenium as a standalone treatment for prostate cancer. Those considering natural extract options should proceed with caution, keeping in mind the current limitations in evidence.
While selenium was noted in our findings, we found that its effectiveness is not straightforward. Specifically, the interaction between selenium and silybin complicated our ability to isolate the impact of selenium on its own. Thus, it became clear that, although some benefits arise from its combined use, we couldn’t definitively conclude that selenium alone delivers significant advantages for prostate cancer treatment.
Overall, the insights from our network meta-analysis suggest that while silybin and selenium together show promise, we need more studies to establish the detailed benefits and safety of selenium as a standalone treatment for prostate cancer. Those considering natural extract options should proceed with caution, keeping in mind the current limitations in evidence.
References
- Zou Y, Xu H, Wu X, Liu X, Zhao J. Enhancing Radiotherapy Sensitivity in Prostate Cancer with Lentinan-Functionalized Selenium Nanoparticles: Mechanistic Insights and Therapeutic Potential. Pharmaceutics. 2024;16. 10.3390/pharmaceutics16091230
- Sochacka M, Hoser G, Remiszewska M, Suchocki P, Sikora K, et al. Effect of Selol on Tumor Morphology and Biochemical Parameters Associated with Oxidative Stress in a Prostate Tumor-Bearing Mice Model. Nutrients. 2024;16. 10.3390/nu16172860
- Alsulami FJ, Shaheed SU. Role of Natural Antioxidants in Cancer. Cancer Treat Res. 2024;191:95. 10.1007/978-3-031-55622-7_4
- Shi Z, Liu M, Zhang X, Wang J, Zhang J, et al. A novel selenium analog of HDACi-based twin drug induces apoptosis and cell cycle arrest via CDC25A to improve prostate cancer therapy. Theranostics. 2024;14:3565. 10.7150/thno.92119
- Huang H, Qin J, Wen Z, Liu Y, Chen C, et al. Effects of natural extract interventions in prostate cancer: A systematic review and network meta-analysis. Phytomedicine. 2024;129:155598. 10.1016/j.phymed.2024.155598
- Whitcomb A, Li X, Lawson J, Christensen M. Response surface methodology optimizes selenium inhibition of prostate cancer PC-3 cell viability. J Trace Elem Med Biol. 2024;84:127414. 10.1016/j.jtemb.2024.127414
- Pietrzak S, Marciniak W, Derkacz R, Matuszczak M, Kiljańczyk A, et al. Correlation between Selenium and Zinc Levels and Survival among Prostate Cancer Patients. Nutrients. 2024;16. 10.3390/nu16040527
- Ghorbani R, Gharbavi M, Sharafi A, Rismani E, Rezaeejam H, et al. Targeted anti-tumor synergistic effects of Myc decoy oligodeoxynucleotides-loaded selenium nanostructure combined with chemoradiotherapy on LNCaP prostate cancer cells. Oncol Res. 2023;32:101. 10.32604/or.2023.044741
- Bissardon C, Proux O, Gazze SA, Filhol O, Toubhans B, et al. Intracellular Fate of Sub-Toxic Concentration of Functionalized Selenium Nanoparticles in Aggressive Prostate Cancer Cells. Nanomaterials (Basel). 2023;13. 10.3390/nano13232999
- Wei B, Tan W, Wang S, Guo Z, Gan S. Interaction between smoking status and dietary selenium intake affects PSA: A cross-sectional study. Urol Oncol. 2023;41:483.e1. 10.1016/j.urolonc.2023.07.009
- Jiang J, Chen B, Tang B, Wei Q. Selenium in Prostate Cancer: Prevention, Progression, and Treatment. Pharmaceuticals (Basel). 2023;16. 10.3390/ph16091250
- Astrain-Redin N, Raza A, Encío I, Sharma AK, Plano D, et al. Novel Acylselenourea Derivatives: Dual Molecules with Anticancer and Radical Scavenging Activity. Antioxidants (Basel). 2023;12. 10.3390/antiox12071331
- Dhillon VS, Deo P, Fenech M. Effect of Selenium and Lycopene on Radiation Sensitivity in Prostate Cancer Patients Relative to Controls. Cancers (Basel). 2023;15. 10.3390/cancers15030979
- Lorenzoni S, Cerra S, Angulo-Elizari E, Salamone TA, Battocchio C, et al. Organoselenium compounds as functionalizing agents for gold nanoparticles in cancer therapy. Colloids Surf B Biointerfaces. 2022;219:112828. 10.1016/j.colsurfb.2022.112828
- Skrajnowska D, Jagielska A, Ruszczyńska A, Idkowiak J, Bobrowska-Korczak B. Effect of Copper and Selenium Supplementation on the Level of Elements in Rats' Femurs under Neoplastic Conditions. Nutrients. 2022;14. 10.3390/nu14061285
- Jin X, Tong W, Sun L, Lu S, Sun P, et al. Association of composite dietary antioxidant index with high risk of prostate cancer in middle-aged and elderly men: insights from NHANES. Front Immunol. 2025;16:1530174. 10.3389/fimmu.2025.1530174
- Es-Sai B, Wahnou H, Benayad S, Rabbaa S, Laaziouez Y, et al. Gamma-Tocopherol: A Comprehensive Review of Its Antioxidant, Anti-Inflammatory, and Anticancer Properties. Molecules. 2025;30. 10.3390/molecules30030653
